This website will be unattended, and will not be open to respond to inquiries.īest wishes for your scientific endeavor. The website, will be open to provide general information, a video demo, and illustrated examples of applications, in vitro, in animals, and in clinical trials. Examples of “real data analysis” and “computer printout” are available in Ref. The applications of MAL-PD/BD/BI and CI have been extended to radiation, photochemistry, environmental, marine, and agricultural studies as well as the anti-SARS-CoV-2 drug evaluations.įor the frequently asked questions (FAQ), the pitfalls and the most common errors in applying the theory to biomedical research, please refer to Refs. For convenience, some specific examples of design and analysis are also provided in the pulldown menus of this website.įor the updates of search trends and applications of MAL-PD/BD/BI and CI theory, please visit the websites of Google Scholar Citations - Ting-Chao Chou and the Web of Science (Publons), [It is noted that one review article published by Chou in 2006 (3) has now received 4,321 citations in 1,135 different biomedical journals, and one theoretical article introducing the concept of combination index (CI) and its algorithm by Chou & Talalay in 1984 (4) has received 7,394 citations in 1,420 journals, internationally, encompassing broad spectrum of biomedical sciences, including, drugs, chemicals, biologicals, regardless of units, mode or mechanism of actions. 3, 9, 15, 16, and in the Appendices of Ref.
Examples of “real data analysis” and “sample computer printouts” are available in Refs.
The conventional concept usually uses many dose-data points to fit empirical curve or empirical formula that have no physical or chemical bearings, and rely heavily on statistical analysis for conclusions.įor the frequently asked questions (FAQ) on MAL-PD, Biodynamics (BD) and Bioinformatics (BI) for experimental design and the simulated diagnostic plots/graphics, the pitfalls and the most common errors in applying the theory to biomedical research, please refer to Refs. By contrast, the conventional biomedical research usually using the “Bottom Up” approach which start with experiments, findings, empirical data analysis, and then hypothesis or speculation. This unique functional dynamics theory/algorithm allows using very few dose-data points to fit the unified general MAL theory, thus to gaining efficiency, cost-effectiveness and automated quantitative simulation. The MAL-PD approach, is an “Up to Down” concept with the unified theory first and applications later. As of, there has been 44,195 downloads by scientists from 137 countries or territories. In 2013, the PD Science LLC was established by Ting-Chao (David) Chou, to take care of scientific affairs of ComboSyn Inc.
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Researchers who are interested and agree with the terms are welcome to register and download the CompuSyn software along with its User’s Guide free of charge.
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On August 1st, 2012, the company announced that as the contribution to the bio-medical research communities, the CompuSyn software has been offered for free download upon registration and adherence to the original terms of usage as indicated in the inner conver of the User's Guide. Dorothy Chou in 2005 with purpose of promoting the pharmacodynamic research and simple computerized analytical simulation using the median-effect principle of the mass-action law (2,3) and its combination index theorem (3,4).ĬomboSyn Inc, which always has vision of not-for–profit purpose, had already recovered the software developmental expense and administration cost. The ComboSyn, Inc., the publisher of CompuSyn software (1), which was set up by Dr.